Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1993-04-20
1994-11-22
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 857, 514 23, A61K 3578, A61K 3512, A61K 3704
Patent
active
053667255
ABSTRACT:
The carcinostatic agent of the present invention is an extract from seeds of Aeginetia indica and has interleukin-2 and interferon-.gamma. inducing potency. As shown in FIG. 1, all of the mice, to which this extract was not given, (.DELTA.) died from tumor (6 mice). In contrast, in the mice, to which the extract was given by 0.6 mg/kg (.quadrature.), 1.2 mg/kg (+), and 2.5 mg/kg ( ) intraperitoneally once in every two days from the day of tumor grafting, all mice showed increase in the survival rate. Thus, the extract exhibits excellent carcinostatic effect.
REFERENCES:
Rosenberg et al., "observations on the Systemic Administration . . . with Metastatic Cancer," 313 New England J. Med. 1485 (1985).
Clark et al., "Interleukin -2 and Lymphokine-Activated . . . Interleukin-2 Regimen," 50 Cancer Reseach 7343, 7347 (1990).
Rosenberg et al., "A Progress Report . . . High Dose Il-2 Alone," 316 New England J. Med. 889 (1987).
West et al., "Constant Infusion Recombinant . . . Adanced Cancer," 316 New England J. Med. 898 (1987).
Rosenberg et al., "A Progress Report . . . High Dose Interleukin 2 Alone," 316 New England J. Med. 889 (1987).
West et al., "Constant Infusion Recombinant . . . Advanced Cancer," 316 New England J. Med. 898 (1987).
Weiner et al., "Phase I Evaluation . . . Interleukin-Z and Y Interferon," 51 Cancer Research 3901 (1991).
Rosenberg et al., "Observations on the Systemic Administration . . . With Metastatic Cancer", 313 New England Journal Med. 1485 (1985).
Clark et al., "Interleukin 2 and Lymphokine-activated . . . Interleukin 2 Regimen," 50 Cancer Research 7343, 7347 (1990).
Weiner et al., "Phase I Evaluation . . . and Y Interferon," 51 Cancer Research 3901 (1991).
Japanese Patent Publication 2-83331 (Okubo et al) Published Mar. 23, 1990 with English language Summary.
Himeno Kunisuke
Okubo Shinya
Sato Mitsunobu
Lee Lester L.
Touzeau Pihyun
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