Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic... – Anti-inflammatory or anti-irritant
Patent
1997-01-28
1998-10-27
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
Anti-inflammatory or anti-irritant
514826, 514914, 424 7804, 424449, 424423, A61K 31765, A61K 3800
Patent
active
058275126
ABSTRACT:
A method is provided for treating a hypersensitivity disease comprising parenterally administering to a human afflicted with such a disease an amount of an anionic polymer effective to counteract the symptoms of a disease selected from the group consisting of bronchial asthma, eosinophil-associated nasal inflammation and vernal conjunctivitis, by counteracting the effect of at least one cationic toxin released by the eosinophils of said human.
REFERENCES:
patent: 3074852 (1963-01-01), Mayron
patent: 3202557 (1965-08-01), Kaufman
patent: 3330729 (1967-07-01), Johnson
patent: 3608063 (1971-09-01), Banker
patent: 4021387 (1977-05-01), Goetzl et el.
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4322402 (1982-03-01), Ishikawa et al.
patent: 4623723 (1986-11-01), Keller et al.
patent: 4795436 (1989-01-01), Robinson
patent: 4816449 (1989-03-01), Hahn
patent: 4937232 (1990-06-01), Bell et al.
patent: 5000936 (1991-03-01), Chibret
patent: 5036056 (1991-07-01), Kludas
patent: 5145677 (1992-09-01), Von Eichbron et al.
patent: 5198350 (1993-03-01), Horisberger et al.
patent: 5200177 (1993-04-01), Leung et al.
patent: 5250293 (1993-10-01), Gleich
patent: 5324510 (1994-06-01), Wegner et al.
patent: 5380716 (1995-01-01), Conrad et al.
"Actimmune", 1993 Physician's Desk Reference Edition 47, pp. 1078-1079 (1993).
"Anionic Polymeric Drugs", L.Guy Donaruma et al., eds., Wiley-Interscience, NY, Chapters 5 and 8, (1980).
"The Merck Index", 11th Ed., p. 1243.
Ahmed, et al., New Engl. J of Med., 329, 90, (1993).
Arm, J.P., et al., "The Pathobiology of Bronchial Asthma", Advances in Immunology, 51, 323-382, (1992).
Ayars, G.H., et al., "Injurious effect of the eosinophil peroxide-hydrogen peroxide-halide system and major basic protein on human nasal epithelium in vitro", Am. Rev. Resp. Dis., 140, 125-131, (1989).
Barker, R.L., et al., "Acidic polyamino acids inhibits human eosinophil granule major basic protein toxicity", FASEB J., 4, Abstr. 26, A1699, (1990).
Barker, R.L., et al., "Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity", J. Clin. Invest., 88, 798-805, (1991).
Bascom, R., et al., "Major basic protein and eosinophil-derived neurotoxin concentrations in nasal-lavage fluid after antigen challenge: effect of systemic corticosteroids and relationship to eosinophil influx", J. Allergy Clin. Immunol., 84, 338-346, (1989).
Berge, S.M., et al., "Pharmaceuticals Salts", J. of Pharma. Sci., 66, 1-19, (1977).
Breslow, D.S., "Biologiaclly active synthetic anionic polymers", Am. Chem. Soc. Symposium Series, 195, 1-9, (1982).
Corringan, C.J., et al., "T Cells and Eosinophils in the Pathogenesis of Asthma", Immunology Today, 13, 501-507, (1992).
DeAngelis, P.L., et al., "Specific recognition of sulfate esters by bindin, a sperm adhesion protein from sea urchins", Biochim. et Biophys. Acta, 1037, 100-105, (1990).
Dunnill, M.S., "The pathology of asthma, with special reference to changes in the bronchial mucosa", J. Clin. Path., 13, 27-33, (1960).
Ellis, A.G., "The Pathological Anatomy of Bronchial Asthma", J. Med. Sci., 136, 407-429, (1908).
Filley, W.V., et al., "Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma", The Lancet, 2, 11-16, (1982).
Frigas, E., et al., "Cytotoxic Effects of the Guinea Pig Eosinophil major basic protein on tracheal epithelium", Lab. Invest., 42, 35-43, (1980).
Frigas, E., "Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma", Mayo Clinic. Proc., 56, 345-353, (1981).
Frigas, E., et al., "The eosinophil and the pathophysiology of asthma", J. Allergy Clin. Immunol., 7oo7, 527-537, (1986).
Fryer, A.D., et al., "Function of Pulmonary M2 Muscarinic Receptors in Antigen-challenged guinea pigs is restored by heparin and Poly-L-glutamate", J. Clin. Invest., 90, 2292-2298, (1992).
Gleich, G.J., "Current understanding of eosinophil function", Hospital Practice, Mar. 15, 1988, 137-160, (1988).
Gleich, G.J., et al., "Cytotoxic Properties of the Eosinophil Major Basic Protein", J. Immunol., 123, 2925-2927, (1979).
Gleich, G.J., "Identification of a Major Basic Protein in Guinea Pig Eosinophil Granules", J. of Exp. Medicine, 137, 1459-1471, (1973).
Gleich, G.L., et al., "Physiochemical and Biological Properties of the Major Basic Protein from Guinea Pig Eosinophil Granules", J. Exp. Med., 140, 313-332(1974),.
Gleich, G.J., "The Eosinophil and bronchial asthma: current understanding", J. Allergy and Clin. Immunol., 85, 422-436, (1990).
Gleich, G.J., et al., "The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity", J. Allergy Clin. Immunol., 81, 776-781, (1988).
Gleich, G.J., et al., "The Eosinophilic Leukocyte: Structure and Function", Adv. Immunol., 39, 177-253, (1986).
Goetzl, E.J., et al., "Eosinophil polymorphonuclear leukocyte function in immediate hypersensitivity", Arch. Pathol., 99, 1-4, (1975).
Gray, P.W., et al., "Interferon-y", Human Cytokines-Handbook for Basic and Clinical Research, Aggarwal, B. B., et al., (eds), Blackwell Scientific Publications, pp. 30-45(1992),.
Gross, N.J., et al., "Allergy, Principles and Practice (3rd edition)", vol. 1, E. Middleton, Jr. et al., eds. (see at p. 790) Anticholinergic Drugs, 792-808, (1988).
Gundel, R.H., et al., "Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates", J. Clin. Invest., 87, 1470-1473, (1991).
Gundel, R.H., et al., "Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates", J. Appl. Physiol., 68, 779-786, (1990).
Hastie, A.T., et al., "The effect of purified human eosinophil major basic protein on mammalian ciliary activity", Am. Rev. Resp. Dis., 135, 848-853, (1987).
Hodnett, E.M., et al., "anionic polymers and biological acitvites. Effects of some new polycarboxylic acids on the Ascitic Sarcoma 180 of Mice", J. Med. Chem., 21, 652-657, (1978).
Horn, B.R., et al., "total Eosinophil counts in the management of bronchial asthma", N. Engl. J. Med., 292, 1152-1155, (1975).
Jacoby, D.B., et al., "Human Eosinophil major basic protein is in endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor", J. Clin. Invest., 91, 1314-1318, (1993).
Kelker, H.C., et al., "Effects of Glycosidase Treatment on the Physicochemical Properties and Biological Activity of Human Interferon-y", J. Biol. Chem., 258, 8010-8013(1983),.
Lane, et al., New Engl. J. of Med., 329, 129, (1993).
Mauser, P.J., et al., "The Effect of Anti-IL-5 on antigen-Induced airway Hyperreactivity and Pulmonary Eosinophilia in guinea Pigs", Am. Rev. Resp. Dis., 145, A859, (1992).
Motojima, S., et al., "Toxicity of Eosinophil cationic proteins for guinea pig tracheal epithelium in vitro", Am. Rev. Respir. Dis., 139, 801-805, (1989).
Ottenbrite, R.M., "Anionic Polymeric Drugs", L.G. Donamura et al., eds., Wiley-Interscience, NY, Chapters one and two, 1-48, (1980).
Sano, E., et al., "Constitutive Long-Term Production and Characterization of Recombinant Human Interferon Gammas from Two Different Mammalian Cells", Cell Structure and Function, 13, 143-159(1988),.
Trocme, S.D., et al., "Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis", Am. J. Opthtamol., 108, 57-63, (1989).
Udell, I.J., et al., "Eosinophil granule major basic protein and charcot-leyden crystal protein in human tears", Am. J. Ophthamol., 92, 824-828, (1981).
Wallen, N., et al., "Glucocorticoids inhibit cytokine-mediated eosinophil survival", J. Immunol., 147, 3490-3495, (1991).
Wardlaw, A.J., et al., "Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma", Am. Rev. Resp. Dis., 137, 62-69, (1988).
Wasmoen, T.L., et al., "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein", J. of Biol. Chem., 263, 125459-12563, (1988).
Weller, P.F., et al., "The Human Eosinophil", Am. J. Pathol., 100, 793-820, (198
Donlar Corporation
Page Thurman K.
LandOfFree
Method for the treatment of bronchial asthma and like hypersensi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the treatment of bronchial asthma and like hypersensi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the treatment of bronchial asthma and like hypersensi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1611989