Method for the treatment and prevention of gastric and duodenal

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4242381, 514 13, 530324, 530300, 530326, 530328, 530327, 530329, 5303871, 5303881, A61K 3900, A61K 3938, A61K 3800, C07K 500

Patent

active

058661280

ABSTRACT:
Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.

REFERENCES:
patent: 3931141 (1976-01-01), Wissman et la.
patent: 4201770 (1980-05-01), Stevens
patent: 4384995 (1983-05-01), Stevens
patent: 4526716 (1985-07-01), Stevens
patent: 4565805 (1986-01-01), Smirnov et al.
patent: 4687759 (1987-08-01), Martinez et al.
patent: 4691006 (1987-09-01), Stevens
patent: 5607676 (1997-03-01), Gevas et al.
patent: 5609870 (1997-03-01), Gevas et al.
patent: 5622702 (1997-04-01), Gevas et al.
Houghlen et al. Vaccines 86 1986 pp. 21-25.
Bowie et al. 1990. Science 247:1306-1310.
Seimann. In: Rodent Tumor Models in Exptal Cancer Therapy Ed. Kallman. 1987. pp. 12-15. Pergamon Press, N.Y.
Bystryn, Cancer & Metastasis Rev. 9:81-91, 1990.
Sugano et al., The Journal of Biological Chemistry, vol. 260, No. 21, Sep. 25, 1985, pp. 11724-11729.
Jaffe et al., Gastroenterology, vol. 58, No. 2, Feb. 1970, pp. 151-156.
Jaffe et al., Surgery, vol. 69, No. 2, Feb. 1971, pp. 232-237.
Jaffe et al., Surgery, vol. 65, No. 4, Apr. 1969, pp. 633-639.
Hughes et al., Digestive Diseases, vol. 21, No. 3, Mar. 1976, pp. 201-204.
Wunsch et al., Z. Physiol. Chem. Jun. 1982, pp. 666-669.
Larsson, Neurohistochemoistry: Modern Methods and Applications, 1986, pp. 527-567.
Moroder et al., Gastrin and Cholecystokinin, Chemistry, Physiology and Pharmacology, 1987, pp. 21-32.
Dockray et al., Gastroenterology, vol. 68, No. 2, Feb. 1975, pp. 222-230.
Choudhury et al., Z. Physiol. Chem., Nov. 1980, pp. 1719-1733.
Azuma et al. Gastroenterologia Japonica, vol. 21, No. 4, Aug. 1986, pp. 319-324.
Varndell et al., Experientia, 39, 1983, pp. 713-717.
Rehfeld et al. Scand. J. Clin. Lab. Invest., 30, 1972, pp. 221-232.
De Magistris et al., Analytical Biochemistry, 102, 1980, pp. 126-133.
Rehfeld et al., Regulatory Peptides, 2, 1981, pp. 333-342.
Yamaguchi, K., et al., Chem. Abs., 100: 154661m, p. 373, (1983).
Dockrey, "Regulatory Peptides", 1, 169-186 (1980).
Nemeth et al. Chem. Abs. 98: 51653W. p. 495, 1982.
Dockray, G. Chem. Abs. 94: 119200W. p. 506, 1980.
Yanaihara et al., "Biomedical Research", 1, 242-247 (1980).
Yanaihara et al., "Gut Peptides", 26-33 (1979).
Kothary, et al., Biochem. Biophys. Res. Com. 146:186-188, 1987.
Larsson, "Characterization of Antral Gastrin Cells with Region-Specific Antiserum", J. Histochem. Cytocem. 25:1317-21, 1977.
Iwanaga, T. Immunocytochenical Localization of the Different Gastrin Forms in the Pyloric Antrum:, Biom. Res. 1:316-320, 1980.
Beauchamp et al., Ann. Surg., 202, Sep. 1985, pp. 303-309.
Dockray, "Amino-terminal gastrin fragment in serum of Sollinger-Ellison Syndrome patients", Gatroenterology 68:222-230, 1975.
Lamote et al., Regulatory Peptides, 20, 1988, pp. 1-9.
Lamers et al., Eur. J. Cancer Clin. Oncol., vol. 24., No. 2, 1988, pp. 267-273.
Watson et al., in vitro, Br. J. Surg., vol. 75, Apr. 1988, pp. 342-345.
Kusyk et al., Am. J. Physiol., 251, 1986, pp. G597-G601.
Weinstock et al., Cancer Research, 48, Feb. 15, 1988, pp. 932-937.
Smith et al., Gastroenterology, 95 1988, pp. 1541-1548.
Rae-Venter et al., Gastroenterology, vol. 80, No. 5, 1986, p. 1256.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for the treatment and prevention of gastric and duodenal does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for the treatment and prevention of gastric and duodenal , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the treatment and prevention of gastric and duodenal will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1114615

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.