Method for the total synthesis of cyclosporins, novel cyclospori

Details Method for the total synthesis of cyclosporins, novel cyclospori Method for the total synthesis of cyclosporins, novel cyclospori

1981-09-03

1983-08-02

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

043965423

ABSTRACT:
A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

REFERENCES:
patent: 4108985 (1978-08-01), Ruegger et al.
patent: 4117118 (1978-09-01), Harri et al.
patent: 4210581 (1980-07-01), Ruegger et al.
patent: 4220641 (1980-09-01), Traber et al.
patent: 4288431 (1981-09-01), Traber et al.
Mori et al., Tetrahedron, vol. 86, pp. 87-90 (1980).
Ko Sawai et al., Agric. Biol. Chem., 45(5), pp. 1223-1228, (1981).

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