Method for the total synthesis of cyclosporins, novel cyclospori

Details Method for the total synthesis of cyclosporins, novel cyclospori Method for the total synthesis of cyclosporins, novel cyclospori

1983-05-05

1985-11-19

Phillips, Delbert R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

560170, 560163, 562567, 546216, 546219, C07C10130, C07D 8736, C07D 2708, C07D 2924

Patent

active

045543518

ABSTRACT:
A method for the total synthesis of cyclosporins, in particular Cyclosporin A, cyclosporins produced in accordance with the method of the invention and novel intermediates, in particular novel [1S, 2R, 3R]- and [1R, 2S, 3S]-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes, employed in the method of the invention.

REFERENCES:
patent: 4108985 (1978-08-01), Ruegger et al.
patent: 4117118 (1978-09-01), Harri et al.
patent: 4210581 (1980-07-01), Ruegger et al.
patent: 4220641 (1980-09-01), Traber et al.
patent: 4288431 (1981-09-01), Traber et al.
patent: 4396542 (1983-08-01), Wenger
Mori et al., Tetrahedrom, 86, 87-90, (1980).
Ko Sawai et al., Agric. Biol. Chem., 45(5), 1223-1228, (1981).
Ruegger et al., Helv. Chim. Acta, 59(112), 1075-1092, (1976).

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