Method for the synthesis of trisodium phosphonoformate hexahydra

Details Method for the synthesis of trisodium phosphonoformate hexahydra Method for the synthesis of trisodium phosphonoformate hexahydra

1995-04-18

1997-01-07

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus acids or salts thereof

C07F 922

Patent

active

055918891

ABSTRACT:
The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50.degree. C., adding triethyl phosphonoformate to said solution at 50.degree. C., heating the reaction mixture to reflux for about 1 hour, cooling of the reaction mixture and filtering-off of the product.

REFERENCES:
patent: 4018854 (1977-04-01), McIntosh
patent: 4966991 (1990-10-01), Gerdau

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