Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-4-aza-bicyclo
Patent
1991-08-02
1993-12-07
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound having a 1-thia-4-aza-bicyclo
435 44, 435 45, 435 46, 435 47, 435 49, 435117, 435118, 435176, 435177, 435178, 435179, 435180, 435228, 435229, 435230, C12P 3700, C12P 3500/35/06, C12N 984
Patent
active
052682714
ABSTRACT:
Synthesis of semi-synthetic monobactamic or .beta.-Lactamic antibiotics by using derivatives stabilized by various methods of penicillin G acylase from various microbial sources according to a thermodynamically controlled strategy in monophase water/cosolvent organic apolar systems, wherein the concentration of the cosolvent varies between 30% and 90%, the temperature between -10.degree. C. and 50.degree. C., the pH between 4.5 and 8.5, with concentrations of the antibiotic nucleus between 0.5 an 875 mM and acyl donor between 0.2 mM and 1M, with a relationship antibiotic ring/activated or free acyl donor, using a buffer between 0 and 1M. Application to the pharmaceutical industry.
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Alvaro Campos Gregorio
Blanco Martin Rosa M.
Fernandez Lafuente Roberto
Guisan Seijas Jose M.
Molina Rosell Cristina
Cosejo Superior de Invetigaciones Certificas
Lilling Herbert J.
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