Method for the synthesis of huperzine A and analogs thereof and

Details Method for the synthesis of huperzine A and analogs thereof and Method for the synthesis of huperzine A and analogs thereof and

1994-07-22

1997-09-02

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546110, 546111, 546 97, 514290, C07D22106, C07D22116, C07D22122

Patent

active

056633440

ABSTRACT:
The present invention relates to a method for the synthesis of certain bridged fused ring pyridines. Such bridged fused ring pyridines can be converted to huperzine A and analogs of huperzine A. The present invention also covers such bridged fused ring pyridines, compounds utilized for the preparation of the bridged fused ring pyridines and analogs of huperzine A. The compounds are capable of inhibiting cholinesterase enzymes and, therefore, are useful as pharmaceutical agents for treatment of disorders involving cholinesterase enzymes. Examples of such disorders include myasthenia gravis, Alzheimer's dementia and the improvement of senile memory loss.

REFERENCES:
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