Method for the synthesis of bis-tetrahydrofuranyl annonaceous ac

Details Method for the synthesis of bis-tetrahydrofuranyl annonaceous ac Method for the synthesis of bis-tetrahydrofuranyl annonaceous ac

1996-07-25

1998-12-15

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30758

Patent

active

058499369

ABSTRACT:
A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

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