Method for the synthesis of anthrapyrazolones

Details Method for the synthesis of anthrapyrazolones Method for the synthesis of anthrapyrazolones

1995-01-10

1997-04-08

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23154

Patent

active

056189443

ABSTRACT:
This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphen yl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

REFERENCES:
patent: 4556654 (1985-12-01), Showalter et al.
patent: 4608439 (1986-08-01), Johnson et al.
patent: 4672129 (1987-06-01), Beylin et al.
G. Zagotto et al., Bioorganic & Medicinal Chemistry, 2(7), 1992, p. 659.
H.D. Showalter et al., J. Med. Chem., 27, 1984, p. 255.
H. Showalter et al., J. Med Chem., 30, 1987, p. 121.
W. R. Leopold, Cancer Research, 45, 1985, p. 5532.
V. G. Beylin et al., J. Heterocyclic Chem., 26, 1989, p. 85.
Tetrahedron Letters (1985) 26: 157-160.
J. Heterocyclic Chemistry (1985) 23: 1491-1502.

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