Method for the synthesis, compositions and use of 2'-deoxy-5-flu

Details Method for the synthesis, compositions and use of 2'-deoxy-5-flu Method for the synthesis, compositions and use of 2'-deoxy-5-flu

1995-06-07

1997-12-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544243, 424450, A61K 31505, A61K 9127, C07D41104

Patent

active

057009376

ABSTRACT:
The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the option of introducing functionality as needed; methods of using these compounds, particularly in the prevention and treatment of AIDS; and the compounds themselves. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds and related compounds.

REFERENCES:
patent: 5047407 (1991-09-01), Belleau et al.

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