Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2005-03-08
2005-03-08
Richter, Johann (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S503000, C562S504000
Reexamination Certificate
active
06864390
ABSTRACT:
The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize steroselectively analogs of gabapentin (Neurontin®) of Formulas (I), (II), (III) and (IV) wherein R is C1-C10alkyl or C3-C10cycloalkyl and pharmaceutically acceptable salts thereof.
REFERENCES:
patent: 9921824 (1999-05-01), None
PCT Search Report, PCT/US00/32570.
Herz, “Azulenes. VII. A Novel Rearrangement in the Synthesis of Azulenes”,Journal of the American Chemical Society, vol. 78, No. 7, pp. 1485-1494, 1956.
Blakemore David Clive
Bryans Justin Stephen
Williams Sophie Caroline
Richter Johann
Scully Scott Murphy & Presser
Warner-Lambert & Company
Zucker Paul A.
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