Method for the simultaneous determination of DNA sequence variat

Details Method for the simultaneous determination of DNA sequence variat Method for the simultaneous determination of DNA sequence variat

1989-05-01

1991-11-26

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435810, 536 27, 935 77, 935 78, 436501, 436808, C12Q 168, C07H 1512, G01N 33566, C12N 1500

Patent

active

050681761

ABSTRACT:
This invention relates to a method of simultaneously determining DNA sequence variations on a large number of loci, and a kit suitable therefor. The method comprises an electrophoretic separation of restriction fragments in two dimensions on the basis of two independent criterions, namely, length and base pair sequence, and a detection of separated fragments by means of a labelled probe comprising one or more units of minisatellite sequences. Preferred probes are GC-rich minisatellite core sequences.

REFERENCES:
Fischer et al (1979), Cell 16, 191-200.
Southern (1975), J. Mol. Biol. 98, 503-517.

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