Method for the separation of antibiotic macrolides

Details Method for the separation of antibiotic macrolides Method for the separation of antibiotic macrolides

1977-10-11

1979-07-03

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435119, 424181, 435886, C07H 1708

Patent

active

041600843

ABSTRACT:
This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described utilizes a column containing a hydroxyalkylated dextran gel as a step in the separation of the desired compounds. The compounds which are isolated and purified are described generically as C-076 and have significant parasiticidal activity.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
Mishima et al., Tetrahedron Letters, No. 10, pp. 711-714, 1975.
Journal of Antibiotics 29(6), Jun. 1976, pp. 76--35 to 76--42 and pp. 76--14 to 76--16.

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