Method for the separation and determination of enantiomeric amin

Details Method for the separation and determination of enantiomeric amin Method for the separation and determination of enantiomeric amin

1988-01-25

1989-04-04

Richman, Barry S.

Chemistry: analytical and immunological testing

Nitrogen containing

Amine and quaternary ammonium

436 86, 436 89, 436161, 436172, 436175, 436178, 558282, G01N 2177, G01N 3368

Patent

active

048187046

ABSTRACT:
The invention relates to a new chiral reagent of the formula ##STR1## wherein X is halogen, an azide group or a succinimidyl group and wherein R is an alkyl group or a trifluormethyl group. The invention further relates to a method for the derivatization, determination and preparation resolution of primary and secondary amino-containing compounds. The method comprises the steps of derivatizing the amino function by the reagent to form diastereomeric carbamates, which are determined by e.g. fluorimetry or absorptiometry after separation by liquid chromatography.

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Carpino et al., J. Org. Chem., vol. 37, No. 22, pp. 3404-3409, 1972.
Glass, J. Agric. Food Chem., vol. 31, pp. 280-282, 1983.
Roseboom et al., Anal. Chim. Acta, vol. 135, No. 2, pp. 373-377, 1982.

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