Method for the selective survival or selective growth of a...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

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C530S388200, C530S387300, C530S388500, C530S391700, C435S018000, C435S231000, C435S007100, C435S252100, C435S260000, C435S038000, C514S002600, C424S178100

Reexamination Certificate

active

06969593

ABSTRACT:
The invention is in particular related to a method for the selective survival or selective growth of a target cell comprising the steps of: a) contacting the target cell with a conjugate compound A-B, wherein A is a selective antibody or antibody derivative recognizing the target cell and B is a biotic agent able to at least partially inactivate an anti-bios agent, said anti-bios agent is able to inhibit the growth of cells; and b) contacting the target cell with the anti-bios agent. The present invention also relates to said conjugate on its own, a selection medium for cells comprising said conjugate and cells that are selected or recognized using a method or conjugate according to the present invention. The present invention further elucidates a pharmaceutical compound or composition, a kit for the detection of a target cell or for the diagnosis of diseases caused by the target cell or a product that can be used in the therapy of infectious related diseases comprising a conjugate according to present invention.

REFERENCES:
patent: WO 97/34634 (1997-09-01), None
patent: WO 98/56425 (1998-12-01), None
Witkowski et al. , Biochemistry 38:11643-11650, 1999.
Seffernick et al. , J. Bacteriol. 183(8):2405-2410, 2001.
Kerr et al. , Bioconjugate Chemistry 10:1084-1089, 1999.
Meyer et al., Preparation and characterization of a beta-lactamase Fab' conjugate for the site-specific activation of oncolytic acents, Bioconjug Chem 3(1): 42-48 (1992).
American Type Culture Collection, Catalogue of Filamentous Fungi, 1991, p 55, Rockville, Maryland.
American Type Culture Collection, Catalogue of Bacteria and Phages. 1992. p. 279. Rockville, Maryland.

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