Method for the selective removal of acyl-functionality...

Details Method for the selective removal of acyl-functionality... Method for the selective removal of acyl-functionality...

2005-01-25

2005-01-25

Trinh, Ba K. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S511000

Reexamination Certificate

active

06846937

ABSTRACT:
A method for removing acyl-groups appended by an ester linkage to the 2′-hydroxyl group present in paclitaxel-related molecules comprising treatment with alcohol under non-acidic conditions. 2′,7-bis-Monochloroacetylpaclitaxel analogs are converted to their corresponding 7-monochloroacetyl derivatives by treatment with alcohol under non-acidic conditions

REFERENCES:
patent: 5679807 (1997-10-01), Murray et al.

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