Method for the safe administration of fatty acid

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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A61K 3120

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active

055083072

ABSTRACT:
Method of safe intravenous administration of fatty acid(s), and in particular the n-6 and n-3 series essential fatty acids and conjugated fatty acids, whereby the fatty acid(s) or a proportion thereof are administered in the form of lithium salts, and whereby the plasma lithium levels are regularly monitored to avoid haemolysis, preferably keeping the lithium level no higher than 0.7 millimolar in the long term and preferably also no higher than 0.4-0.5 millimolar in the first 24-48 hours or, where only a proportion of the fatty acids are administered as lithium salts, a corresponding proportion of said levels.

REFERENCES:
patent: 5252333 (1993-10-01), Horrobin
Derwent Publications Ltd., London, GB: AN 91-152285 & JP-A-3 086 819 (Nippon Oils & Fats KK), 11 Apr. 1991 (Abstract).
Cancer Reserach, vol. 51, No. 22, 15 Nov. 1991, pp. 6025-6030, Cornelius et al: "Cytotoxic Effect of CIS-Parinaric Acid in Cultured Malignant Cells".

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