Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1989-11-07
1991-04-23
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C07D47504
Patent
active
050101943
ABSTRACT:
A method for the resolution of (6R,S)-folinates into their diastereomers, comprising adding a water-soluble alkali metal, ammonium or alkaline earth metal salt of an inorganic or organic acid to an aqueous solution of a salt of (6R,S)-folinic acid, removing by filtration the salt which separates out, which consists predominantly of the corresponding (6R)-folinates, and isolating the desired (6S)-folinate from the filtrate.
REFERENCES:
patent: 2688018 (1954-08-01), Cosulich
patent: 4148999 (1979-04-01), Temple et al.
patent: 4500711 (1985-02-01), Wisowaty
patent: 4959472 (1990-09-01), Wood et al.
Mueller et al., Chem. Abstr., vol. 111, entry 102722q (1988), abstracting WO 88 08 844.
Chem. Abstr. vol. 98, entry 215624r (1983).
Straw et al, Cancer Res., vol. 44, pp. 3114-3119 (1984).
Swiss Confederation Federal Bureau of Intellectual Property Disclosure of Invention, published May 2, 1955, No. 305574, Class 116h, Appln. filed May 3, 1952, "Process for the Preparation of Calcium 5-Formyl-5,6,7,8-Tetrahydropteroylglutamate."
Temple et al., Jour. Med. Chem. 1979, vol. 22, No. 6, pp. 731-734.
Chem. Abstracts, vol. 107, entry 214060w (1987).
Merck Index, 10th Edition (1983), Entry 4111.
Russian Article: Kaplan et al., Biologiceskie Nauki, vol. 7, pp. 22-37 (1987).
Fontecilla-Camps et al., Chemistry and Biology of Pteridines, p. 235, Elsevier/North-Holland, NY.
J. Feeney, Biochemistry, vol. 20, pp. 1837-1842 (1981).
Cosulich, J. Am. Chem. Soc., vol. 74, pp. 4215-4216 (1952).
J. Am. Chem. Soc., vol. 101:20, pp. 6114-6115 (Sep. 26, 1979).
Rees et al., "A Simple and Effective Method for the Preparation of 6(R)-and 6(S)-Diastereoisomers," J. Chem. Soc., Chem. Commun., pp. 470-472 (1987).
Rees et al., Tetrahedron, vol. 42, No. 1, pp. 117-137 (1986).
Kaufman et al., The Journal of Biological Chemistry, vol. 238, No. 4, pp. 1498-1500 (Apr. 1963).
White et al., The Journal of Biological Chemistry, vol. 253, No. 1, pp. 242-245 (Jan. 10, 1978).
Fachlexikon ABC Chemie, Stereoisomeric, p. 1077 (1987).
Rowe, Analytical Biochemistry 22, pp. 166-177 (1968).
Choi et al., Analytical Biochemistry 168, pp. 398-404 (1988).
Folates and Pterins, vol. 1, Chemistry and Biochemistry of Folates, pp. xiii and 99 (1984).
Kalbermattan et al., Helvitica Chemica Acta, vol. 64, Fasc. 8, Nr. 266, p. 2627 (1981).
Conti Josef
Mueller Hans R.
Muerdel Guenter
Ulmann Martin
Daus Donald G.
Eprova AG
LandOfFree
Method for the resolution of folinic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the resolution of folinic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the resolution of folinic acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1622528