Method for the removal of interfering substances, including caff

Details Method for the removal of interfering substances, including caff Method for the removal of interfering substances, including caff

1981-12-24

1984-07-17

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

210656, 436 96, 436 98, 436175, 436178, 436815, 436825, G01N 3106, G01N 3350, G01N 3354

Patent

active

044606958

ABSTRACT:
A method for the separation of theophylline and caffeine contained in body fluids is provided. A macroreticular styrene-divinylbenzene copolymer resin activated by a protic solvent is utilized. The body fluid is eluted with water in an isocratic manner to afford a theophylline sample uncontaminated with caffeine. Such samples are useful in immunoassay procedures for the measurement of theophylline.

REFERENCES:
patent: 3531463 (1970-09-01), Gustafson
Extraction of Drugs from Biofluids and Tissues with XAD-2 Resin P.A.F. Pranitis, Journal of Forensic Sciences, vol. 19, (1974).
Application Note by E. I. duPont de Nemours and Company, PREP.TM. I Automated Sample Processor.
Chemical Abstracts I, 91: 2174n, (1979).
Chemical Abstracts, Chemical Substance Index, vol. 91, (Pp-Z), p. 4889cs, col. 2, (1979).
Chemical Abstracts II, 92: 87759a, (1980).

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