Method for the removal of interfering substances in theophylline

Details Method for the removal of interfering substances in theophylline Method for the removal of interfering substances in theophylline

1983-04-22

1984-10-16

Adee, John

Liquid purification or separation

With means to add treating material

Chromatography

210656, 210636, 422 70, B01D 1500

Patent

active

044773463

ABSTRACT:
An apparatus for the separation of theophylline and caffeine contained in body fluids is provided. A macroreticular styrene-divinylbenzene copolymer resin activated by a protic solvent is utilized. The body fluid is eluted with water in an isocratic manner to afford a theophylline sample uncontaminated with caffeine. Such samples are useful in immunoassay procedures for the measurement of theophylline.

REFERENCES:
patent: 3966596 (1976-06-01), Stevens et al.
patent: 4243534 (1981-01-01), Bulbenko
patent: 4338404 (1982-07-01), Tanaka et al.
patent: 4353801 (1982-10-01), Mukoyama et al.
Chromatographic and Allied Methods by Mikes, John Wiley & Sons of New York, pp. 221-225, 1979.

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