Method for the reduction or prevention of post-surgical...

Details Method for the reduction or prevention of post-surgical... Method for the reduction or prevention of post-surgical...

2007-04-03

2007-04-03

Saucier, Sandra E. (Department: 1651)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C514S002600

Reexamination Certificate

active

10399223

ABSTRACT:
Reducing or preventing adhesions which would form in a patient during or after surgery by administering to the wound surface of a patient a fibrinogen solution in an amount of about 0.025 ml fibrinogen/cm2to about 0.25 ml fibrinogen/cm2of the surface being at risk for developing adhesions. User of fibrinogen in a preparation comprising fibrinogen at a concentration of 20 to 80 mg/ml for the reduction or prevention of post-surgical adhesion formation.

REFERENCES:
patent: 99/56797 (1999-11-01), None
Jahoda et al., “Fibrin sealant inhibits connective tissue deposition in a murine model of peritoneal adhesion formation”, Surgery 125 (1) : 53-59 (1999).
Lindenberg et al., “Prevention of peritoneal adhesion formation by fibrin sealant”, Annales Chirurgiae et Gynaecologiae 73 : 11-13 (1984).
Aliredjo et al., “The use of Gore-Tex membrane for adhesion prevention in tethered spinal cord surgery; Technical case reports”, Neurosurgery 44 (3) : 674-678 (1999). abstract only.

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