Method for the reduction of mucin viscosity

Details Method for the reduction of mucin viscosity Method for the reduction of mucin viscosity

1979-07-31

1984-01-03

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424128, 424224, 424258, 424263, 424326, 424336, 546300, 546162, A01N 3166, A01N 3115, A01N 3144, A01N 3147

Patent

active

044242166

ABSTRACT:
A method for reducing mucin viscosity which comprises administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce free sulfhydryl groups.

REFERENCES:
patent: 3892824 (1975-07-01), Piper et al.
"Studies on the Reduction of Sputum Viscosity in Cystic Fibrosis Using an Orally Absorbed Protected Thiol", Tabachnik, Peterson, and Cerami, Apr. 22, 1980; vol. 214, No. 2; pp. 246-249.
"Protein Binding of N-2-Mercaptoethyl-1,3-Diaminopropane via Mixed Disulfide Formation after Oral Administration of WR 2721.sup.1 ", Tabachnik, Blackburn, Peterson and Cerami; vol. 220, No. 2; Oct. 19, 1981; pp. 243-246.
"Biochemical and Rheological Characterization of Sputum Mucins from a Patient with Cystic Fibrosis", Tabachnik, Blackburn, and Cerami; vol. 256, No. 14; Jul. 25, 1981, pp. 7161-7165.
Survey of Compounds which have been Tested for Carcinogenic Activity, pp. 21,23,113,153,154,469; Thompson and Co., Publishers, DHEW Pub. No. (NIH)72-35 (1968-1969 volume).

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