Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1983-06-01
1984-10-02
Welsh, Maurice J.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
210651, 525 5421, C07G 702, C07G 700
Patent
active
044746903
ABSTRACT:
A method is disclosed for the recovery of a peptide-containing compound from a solution by the use of a ligand attached to a carrier which ligand is capable by biospecific affinity of fixing onto the peptide-containing compound. The carrier which, for example, may be a soluble macromolecule, e.g., cellulose or dextran, with ligand attached thereto, is utilized in dissolved form. The choice of ligand is determined by the type of peptide-containing compound for which it is to be used. Example of ligands which may be used are immunoglobulins, Fc-receptors, certain surface receptors from bacteria, e.g., protein A from S. aureus, co-factors and certain sugar-containing proteins. The ligand may be attached to the carrier by bonds of a covalent character, which may be achieved by periodate activation and subsequent coupling or by diimidazole coupling.
REFERENCES:
patent: 3502545 (1970-03-01), Westman et al.
patent: 3687928 (1972-08-01), Brouwer et al.
patent: 3867501 (1975-04-01), Hanushewsky
patent: 4066505 (1978-01-01), Schneider
patent: 4402874 (1983-09-01), Johnson et al.
Gambro Lundia AB
Nutter Nathan M.
Welsh Maurice J.
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