Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-04-19
1996-08-20
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435 9151, 536 2431, C12Q 168, C12P 1934, C07H 2100
Patent
active
055478387
ABSTRACT:
An improved method is disclosed for diagnosing the presence of a chromosomal translocation characteristic of acute myelogenous leukemia. Nucleic acid molecules that may be used in this improved method are described.
REFERENCES:
patent: 5057410 (1991-10-01), Kawasaki et al.
Popp, S., et al. Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ . . . Cancer Genet.Cytogenet.(Nov. 1991) 57:103-107.
Rabbitts, T., " Translocations, Master Genes, and Acute Differences between the Origins of Acute and Chronic Leukemias," Cell 67:641-644 (1991).
Cleary, M. L., "Oncogenic Conversion of Transcription Factors by Chromosomal Translocations", Cell 66:619-622 (1991).
Sawyers, C. L. et al., "Leukemia and the Disruption of Normal Hematopoieses," Cell 64:337-350 (1991).
Borrow, J. et al., " Moleacular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17," Science 249:1577-1580 (1990).
de Th e, H. et al. "The t(15;17) Translocation of Acute Promyelocytic Leukaemia Fuses the Retinoic Acid Receptor .alpha. Gene to a Novel Transcribed Locus," Nature 347:558-561 (1990).
Alcalay, M. et al., "Translocation Breakpoint of Acute Promyelocytic Leukemia within the Retinoic Acid Receptor .alpha. Locus," Proc. Natl. Acad. Sci. (U.S.A.) 88:1977-1981 (1991).
von Lindern, M. et al., "The (6;9) Chromosome Translocation, Associated with a Specific Subtype of Acute Nonlymphocytic Leukemia, Leads to Aberrant Transcription of a Target Gene on 9q34," Molec. Cell. Biol. 10:4016-4026 (1990).
Solomon, E. et al., "Chromosome Aberrations and Cancer," Science 254:1153-1160 (1991).
Miyoshi, H. et al., "t(8;21) Breakpoints on Chromosome 21 in Myeloid Leukemia Are Clustered within a Limited Region of a Single Gene, AML1," Proc. Natl. Acad. Sci. (U.S.A.) 88:10431-10434 (1991).
Erickson, P. et al., "Identification of Breakpoints in t(8;21) Acute Myelogenous Leukemia and Isolation of a Fusion Transcript, AML1/ETO, With Simlarity to Drosophila Segmentation Gene, runt," Blood 80:1825-1831 (1992).
Gao, J. et al., "Isolation of a Yeast Artificial Chromosome Spanning the 8;21 Translocation Breakpoint t(8;21)(q22;q22.3) in Myelogenous Leukemia," Proc. Natl. Acad. Sci.(U.S.A.) 88:4882-4886 (1991).
Kearney, L. et al., "DNA Sequences of Chromosome 21-Specific YAC Detect the t(8;21) Breakpoint of Acute Myelogenous Leukemia," Cancer Genet. Cytogenet. 57:109-119 (1991).
Daga, A. et al., "Leukaemia/Drosophila Homology," Nature 356:484 (1992).
Xiong, Y. et al., "Molecular Cloning and Chromosomal Mapping of CCND Genes Encoding Human D-Type Cyclins," Genomics 13:575-584 (1992).
Xiong, Y. et al., "Human D-Type Cyclin," Cell 65:691-699 (1991).
Hunter, T. et al., "Cyclins and Cancer," Cell 66:1071-1074 (1991).
Motokura, T. et al., "A Novel Cyclin encoded by a bcl1-Linked Candidate Oncogene," Nature 350:512-515 (1991).
Withers, D. A. et al., "Characterization of a Candidate bcl-1 Gene," Molec. Cell. Biol. 11:4846-4853 (1991).
Chomczynski, P. et al., "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction," Anal. Biochem. 162:156-159 (1987).
Nisson Paul E.
Sacchi Nicoletta
Auerbach Jeffrey I.
Jones W. Gary
Life Technologies Inc.
Schreiber David
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