Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving uric acid
Patent
1982-10-25
1985-11-19
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving uric acid
435 11, 435 14, 435 25, 435 28, 435189, 435267, 435269, 436 71, 436 95, 436 97, 436175, 436825, C12Q 160, C12Q 154, C12Q 162, C12Q 126, C12Q 125, C12N 902, C07G 1700, C07G 700
Patent
active
045542490
ABSTRACT:
A novel enzyme of bilirubin oxidase produced by a genus Myrothecium or genus Coprinus origin microorganism and a conventional enzyme of laccase are found, in the presence of a specific additive compound, e.g. a surface active agent, aromatic carboxylic acid, sulfa drug or protease, to oxidize both conjugated and unconjugated bilirubin in biological fluid to biliverdin without formation of hydrogen peroxide, such that in the case of conventional enzymatic methods of the quantitative determination of glucose, cholesterol, neutral fats, free fatty acids, phospholipids or uric acid all existing together with bilirubin in biological fluid, the usual interference with such determination, as otherwise caused by bilirubin coexisting in such fluid, can be prevented by adding such a bilirubin oxidase or laccase together with such a specific additive compound to the determinative reaction system.
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Murao, S. and Tanaka, N., "Isolation and Identification of a Microorganism Producing Bilirubin Oxidase", Agric. Biol. Chem., vol. 46, No. 8 (1982), pp. 2031-2034.
Nakamura, T., "Purification and Physico-Chemical Properties of Laccase", Biochinica et Biophysica Acta, vol. 39 (1958), pp. 44-52.
Wilkinson, J. H., The Principles and Practice of Diagnostic Enzymology, Chicago, Edward Arnold (1976), pp. 553-555.
Hirano Kenichi
Kosaka Akira
Matsunaga Kuniyoshi
Murao Sawao
Tanaka Noriaki
Amano Pharmaceutical Company Limited
Giesser Joanne
Wiseman Thomas G.
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