Method for the purification of liponic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...

Reexamination Certificate

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C554S191000

Reexamination Certificate

active

07091368

ABSTRACT:
The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

REFERENCES:
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Nakata. “Biologically active lipoic-acid-like substances in urine. II. Purification and chemical properties”, Chemical Abstracts, vol. 71, No. 25, p. 24, 119752c 1969.
Bringmann et al. “A Short and Productive Synthesis of (R)-alpha-Lipoic Acid”, Z. Naturforsch., vol. 54b. pp. 655-661 1999.
Adger et al. “The Synthetis of (R)-(+)-Lipoic Acid using a Monooxygenase-Catalysed Biotransformation as the Key Step”, Bioorganic & Medicinal Chemistry, vol. 5, pp. 253-261 1997.
Yadav et al. “Synthesis of alpha-lipoic acid- A highly useful biologically active compound”, Journal of Scientific & Industrial Research, vol. 49, pp. 400-409 1990.
Gopalan et al. “Stereochemical Control of Yeast Reductions: Synthesis of R-(+)-alpha-Lipoic Acid”, Tetrahedron Letters, vol. 30, pp. 5705-5708 1989.
Brookes et al. “Proof that the Absolute Configuration of Natural alpha-Lipoic Acid is R by the Synthesis of its Enantiomer [(S)-(−)-alpha-Lipoic acid] from (S)-Malic Acid”, J. Chem. Soc., Chem. Commun., pp. 1051-1053 1983.

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