Method for the production of ribavirin using high robose donor c

Details Method for the production of ribavirin using high robose donor c Method for the production of ribavirin using high robose donor c

1987-09-17

1989-06-20

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 85, 435840, C12P 1935, C12P 1928, C12R 113

Patent

active

048408999

ABSTRACT:
A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from Brevibacterium acetylicum is disclosed. The method is characterized in that the ribose donor is guanosine; the concentration of the donor is above about 100 mM; and the enzyme preparation is added before the reaction mixture gells. The method is capable of high production rates and high concentration of the final product.

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