Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Reexamination Certificate
2007-12-18
2007-12-18
Saucier, Sandra E. (Department: 1651)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
C435S041000, C435S132000, C435S155000
Reexamination Certificate
active
10501339
ABSTRACT:
The invention relates to a method for the production of resveratrol in cell cultures. The inventive method consists in: incubating a culture of cells which produce resveratrol naturally, in suspension, in the presence of randomly-methylated β-cyclodextrin (RMBCD) with a degree of substitution of between 11 and 13 under conditions that allow resveratrol synthesis and the excretion of same into the culture medium; and, if desired, isolating the resveratrol produced from said culture medium. The resveratrol can be used in the production of pharmaceutical or nutraceutical products.
REFERENCES:
Bako,P; Fenichel,L; Toke,L; Szente,L; Szejtli,J. “Methylation of Cyclodextrins by Phase-Transfer Catalysis”, Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 1994, 18, 307-314.
Morales, M. et al., Effect of dimethyl-beta-cyclodextrins on resveratrol metabolism in Gamay grapevine cell cultures before and after inoculation withXylophilus ampelinus, Plant Cell Tissue and Organ Culture, 1998. vol. 53, No. 3, pp. 179-187.
CN 1292415 A (Wei Yahui) Apr. 25, 2001 (Resumen) (en linea) (recuperado el Mar. 4, 2003). Recuperado de EPO EPODOC Database.
Bru Martinez Roque
Pedreno Garcia Maria del los Angeles
Arent & Fox LLP
Kosar Aaron J
Saucier Sandra E.
Universidad de Alicante
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