Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing sulfur-containing organic compound
Reexamination Certificate
2007-01-02
2007-01-02
Carr, Deborah D. (Department: 1621)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing sulfur-containing organic compound
Reexamination Certificate
active
10493630
ABSTRACT:
The invention relates to a method for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-IIin which R has the meaning C1-4-alkyl, from 8-chloro-6-oxooctanoic acid alkyl esters of the general formula Iin which R has the above meaning, by enzymatic reduction using alcohol dehydrogenases, such asLactobacillus brevisorThermoanaerobium brokii, in the presence of cofactor regeneration systems.The resulting (R)- and (S)-8-chloro-6-hydroxyoctanoic acid esters can be converted in a known manner into (R)-α-lipoic acid and (S)-α-lipoic acid, respectively.
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Laban Gunter
Müller Michael
Sauer Wolfgang
Carr Deborah D.
Hobbs Ann S.
Venable LLP
Viatris GmbH & Co. KG
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