Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1995-08-01
1999-03-02
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
424 951, 12866202, A61K 4904
Patent
active
058766979
ABSTRACT:
An imaging agent for ultrasound to be administered into a vein is provided. More specifically, an imaging agent for ultrasound containing microbubbles, which has a long-life and is stable within a human body even after is has passed through a lung, and a method for producing the same, are provided.
A method for producing an imaging agent for ultrasound comprises a mixing step wherein a mixture of water, Sodium Stearate, Saponin and CaCl.sub.2 and gas are mixed by a homogenizer for forming bubbles, and a separation step wherein bubbles having a desired size are separated according to their buoyancy after the mixing step. The mixing step further includes two stages, i.e., a low speed mixing stage and a high speed mixing stage. In the low speed mixing stage, a shaft of the homogenizer is immersed into a solution containing a preset amount of Sodium Stearate, Saponin, and CaCl.sub.2, which is mixed at a low rotation speed for a given period of time and is then left for a given period. Then, such a process is repeated. In the high speed mixing stage, said solution is mixed for a given period at a high rotaion speed. After this 2-stage mixing step, the separation is performed by using a burette, thereby obtaining microbubbles of a desired size.
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Gakko Houjin Toin Gakuen
Hartley Michael G.
Hollinden Gary E.
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