Compositions – Inorganic luminescent compositions – Tungsten containing
Patent
1990-07-10
1993-06-01
Lovering, Richard D.
Compositions
Inorganic luminescent compositions
Tungsten containing
424 2, 424 9, 436173, 12866202, 1286534, 514938, 252314, B01J 1300, A61K 4900, A61K 9107, B01F 304
Patent
active
052156800
ABSTRACT:
This invention relates to a large scale method for the production of medical grade lipid-coated microbubbles, to the paramagnetic labeling of such microbubbles and to therapeutic applications for the microbubbles. More particularly, the invention relates to a method of the production of medical grade, concentrated suspensions of stable, paramagnetically derivatized or underivatized microbubbles useful for ultrasonic and magnetic resonance imaging and also relates to therapeutic interventions such as selective tumor destruction.
REFERENCES:
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4572203 (1986-02-01), Feinstein
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4774958 (1988-10-01), Feinstein
patent: 4832941 (1989-05-01), Berwing et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4927637 (1990-05-01), Morano et al.
patent: 4985233 (1991-01-01), Klaveness et al.
patent: 5078986 (1992-01-01), Bosworth et al.
patent: 5088499 (1992-02-01), Unger
Carr et al, "Intravenous Chelated Gadolinium As A Contrast Agent In NMR Imaging Of Cerebral Tumors", Lancet, pp. 484-486 (Mar. 3, 1984).
Lauffer et al, "Preparation and Water Relaxation Properties of Proteins Labeled with Paramagnetic Metal Chelates", Mag. Res. Imaging, 3:11-16 (1985).
Lauffer et al, "1/T.sub.1 NMRD Profiles of Solutions of Mn.sup.2+ and Gd.sup.3+ Protein-Chelate Conjugates", Mag. Res. Med., 3:541-548 (1986).
Quan et al, "Applicators for generating ultrasound-induced hyperthermia in neoplastic tumours and for use in ultrasound physiotherapy", Phys. Med. Biol., 34:1719-1731 (1989).
Runge et al, "Initial Clinical Evaluation of Gadolinium DTPA For Contrast-Enhanced Magnetic Resonance Imaging", Mag. Res. Imaging, 3:27-35 (1985).
ter Haar et al, "High intensity focused ultrasound--a surgical technique for the treatment of discrete liver tumours", Phys. Med. Biol., 34:1743-50 (1989).
Cavitation-Control Technology, Inc.
Covert John M.
Lovering Richard D.
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