Method for the production of human T-T cell hybrids and producti

Details Method for the production of human T-T cell hybrids and producti Method for the production of human T-T cell hybrids and producti

1984-05-31

1989-06-27

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 4351722, 435948, 530351, 530837, 935 93, 935101, C12N 500, C12P 2100, C12R 191, C07K 1506

Patent

active

048430048

ABSTRACT:
A new method is described for fusing and selecting human-human hybrid cells. The selection process begins after longer incubation times in culture medium and involves selection without using HAT or any other drug regimen. Certain T-T cell hybrids produced in this manner secrete suppressor factor.

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patent: 4510244 (1985-04-01), Parks et al.
patent: 4544632 (1985-10-01), Yamamura et al.
patent: 4665032 (1987-05-01), Laurence
patent: 4728614 (1988-03-01), Lau
Arnold, Bernd; "Selection of T-Cell Hybridomas by the Fluorescence-Activated Cell Sorter"; Monoclonal Antibodies and T-Cell Hybridomas, ed. Hammerling et al., .COPYRGT.1981; pp. 560 and 561.
Davis et al., "A Simple Single-Step Technique for Selecting and Cloning Hybridomas for the Production of Monoclonal Antibodies"; J. Immunol. Methods, vol. 50 (1982); pp. 161-171.
Gershon et al.; "Properties of a Somatic Hybrid between Mouse Cells with Different Genotypes"; Nature, vol. 198 (1963); pp. 912-913.
Laurence, J. et al.; "Soluble Suppressor Factors in Patients with Acquired Immune Deficiency Syndrome and Its Prodrome"; J. Clin. Invest., vol. 72, Dec. 1983, pp. 2072-2081.
Greene et al., "Production of Human Suppressor T Cell Hybridomas", J. of Immunology, vol. 129, No. 5, pp. 1986-1992 (1982).
Grillot-Courvalin et al., "Establishment of a Human T-Cell Hybrid Line with Suppressive Activity", Nature, vol. 292, pp. 844-845 (1981).

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