Method for the production of folic acid

Details Method for the production of folic acid Method for the production of folic acid

1994-01-06

1995-04-25

Daus, Ronald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

558190, 560 35, 562440, 568494, C07D47504

Patent

active

054100569

ABSTRACT:
The present invention is directed to a novel process for the production of folic acid in high yield utilizing a novel diimine as an intermediate. This diimine is formed by reacting 2-substituted malondialdehyde with p-aminobenzoyl-L-glutamic acid. This diimine may be converted into folic acid by reacting said diimine with triaminopyrimidinone in the presence of sulphite.

REFERENCES:
patent: 5334957 (1994-09-01), Bouy
Angier, et al. (JACS, 70) (1948), 25) Synthesis of Pteroylglutamic Acid. III.
Eistert, et al. (Chem. Ber 88 (1955), 939, Investigations with triose reductone.
Abstract of the Eistert publication: Investigations with triose reductone (1955).

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