Method for the production of crystalline amino-protected-beta-be

Details Method for the production of crystalline amino-protected-beta-be Method for the production of crystalline amino-protected-beta-be

1987-01-07

1987-12-15

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560163, C07C125065

Patent

active

047134801

ABSTRACT:
An amino-protected L-aspartic acid, such as t-butyloxycarbonyl-beta-benzyl-L-aspartic acid, is prepared by first forming the amino-protected compound in the presence of a tertiary amine base having a pK.sub.a value of about 9 to about 12, water, and a water-immiscible polar organic solvent so as to produce a non-aqueous solution containing a salt form of amino-blocked-beta-benzyl-L-aspartic acid. The thus produced non-aqueous solution is then isolated, or next acidified and treated further to ultimately recover therefrom the amino-protected L-aspartic acid in crystalline form.

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patent: 4440692 (1984-04-01), Kalbacher

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