Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1997-12-19
1999-06-29
Lankford, Jr., Leon B.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435189, 435190, 435191, 564463, C12P 702
Patent
active
059167866
ABSTRACT:
The disclosure describes a method for the preparation of chiral 1,3-aminoalcohols in high optical purity. The method combines the stereoselective oxidation of a 1,4-diol to a gamma-lactone using an alcohol dehydrogenase, the conversion of the gamma-lactone to the corresponding 4-hydroxyamide, 4-hydroxyhydroxamic acid, or 4-hydroxyhydrazide, and stereospecific rearrangement of the 4-hydroxyamide, 4-hydroxyhydroxamic acid, or 4-hydroxyhydrazide to the corresponding chiral 1,3-aminoalcohol.
REFERENCES:
patent: 3668199 (1972-06-01), Szmuskovicz
patent: 5200561 (1993-04-01), Konya et al.
1948 J.H. Saunders and R.J. Slocombe, Chem. Rev., 43, pp. 203-218.
1971 D.V. Banthorpe in "The Chemistry of The Azido Group," Chapter 7, pp. 397-405.
1980 J.D. Warren and J.B. Press, Synth. Comm., 10, pp. 107-110.
1969 P.A.S. Smith, Trans. N.Y.Acad. Sci. 31, pp. 504-515.
1973 S. Simons, Jr. J. Org Chem., 38 pp. 414-416.
1976 W.L.F. Amarego et al, J. Chem. Soc. Perkin Trans. I, 2229-2237.
1974 S. Bittner et al, Tetrahedron Letters, 23 pp. 1965-1968.
1974 L. Bauer and O. Exnor, Argew. Chem. Int. Edition, 13, pp. 376-384.
1946 P.A.S. Smith, Organic Reactions III, Chapter 9, pp. 337-338.
1980 Z. Shaked and G. Whitesides, J. Am. Chem. Soc. 102, 7104-7105.
1984 J. B. Jones and T. Takamura, Canadian Journal of Chemistry, 62, 77-80.
1949 E.S. Wallis and J. Flane, Organic Reactions III, Chapter 7, pp. 267-306.
1975 M. Fetizon et al, Tetrahedron, 31 pp. 171-176.
1985 G.L. Lemiere et al, Tetrahedron Letters, 26, pp. 4527-4528.
1986 G.L. Lemiere in "Enzymes as Catalysts for Organic Synthesis," pp. 19-34, M. Schneider, Editor.
1979 I. J. Jakovac. and J. B. Jones, J. Org. Chem. 44 pp. 2165-2168.
1985 J. B. Jones and I. J. Jakoac. Org. Synth. Coll. Vol. pp. 406-410.
1992 J. B. Jones and I. J. Jakovac in "Preparative Biotransformations" SM. Roberts, Editor, pp. 311-316.
BioCatalytics, Inc.
Lankford , Jr. Leon B.
LandOfFree
Method for the production of chiral 1,3-aminoalcohols does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the production of chiral 1,3-aminoalcohols, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the production of chiral 1,3-aminoalcohols will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1375051