Method for the production of biologically active polypeptides in

Details Method for the production of biologically active polypeptides in Method for the production of biologically active polypeptides in

1994-08-17

1999-09-28

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 435 691, 435 697, 4353201, 935 60, C12N 500, C12N 1500, C12N 2106, C12N 2104

Patent

active

059591714

ABSTRACT:
A process is disclosed for the production of a protein or polypeptide in the milk of a transgenic non-human mammal where the protein or polypeptide is produced as fusion protein with another protein. The fusion protein can then be cleaved to release the protein or polypeptide. This method would reduce or prevent the formation of side effects associated with ectopic expression or leakage of the protein or polypeptide. Such a fusion protein is .beta.-lactoglobulin-EPO, where biologically active EPO is released upon cleavage of the fusion protein.

REFERENCES:
patent: 4873316 (1989-10-01), Meade et al.
Archibald et al (1990) Proced. Natl. Acad. Sci. 87, 5178-5182.
Luthi et al (1992) Eu. J. Biochem. 205, 483-490.
Massoud et al (1996) Reprod. Nutr. Devel. 36, 555-563.
Archer et al (1994) Proc. Nat. Acad. Sci. 91, 6840-6844.

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