Method for the production of azaphenothiazines

Details Method for the production of azaphenothiazines Method for the production of azaphenothiazines

1995-04-17

1996-07-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 34, 546264, 546312, C07D51304, C07D40112

Patent

active

055391079

ABSTRACT:
A process for the production of azophenothiazine derivatives having either of the following structures: ##STR1## where X and Y include alkyl, alkoxy, halogen, hydrogen, carboxy, or carboxy alkyl substituents. These compounds are precursors to pharmaceutically active compounds such as pipacetate. The process involves the reaction of a 2-chloropyridine with a 2-mercaptoaniline or a dimer of 2-(2-mercaptophenylamino)pyridine in an inert solvent, e.g., .gradient.-methylpyrolidone in the presence of an oxidizing agent, e.g., performic acid.

REFERENCES:
patent: 3010961 (1928-11-01), Schindler
Maki, Y. Rearrangement Reaction. XI. Smiles Re-arrangement on Pyridine Derrivatives. Journal of the Pharmaceutical Society of Japan. vol. 86, pp. 50-54 (1966).

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