Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide
Patent
1992-07-10
1994-06-07
Knode, Marian
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using a micro-organism to make a protein or polypeptide
435171, 530317, 530321, 514 11, C12P 2104
Patent
active
053189019
ABSTRACT:
A cyclosporin derivative with incorporated "8-(3-fluoro-D-alanine)" or "8-(2-deutero-3-fluoro-D-alanine)" has been isolated from the fermentation broth of incubating Tolypocladium inflatum MF5080 (NRRL 8044) with 3-fluoro-D-alanine or its 2-deuterated isomer respectively. The modified cyclosporins exhibit immunosuppressive properties.
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Goegelman Robert T.
Patchett Arthur A.
White Raymond F.
DiPrima Joseph F.
Knode Marian
Merck & Co. , Inc.
Panzer Curtis C.
Rose David L.
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