Method for the production of 9-amino-6-demethyl-6-deoxytetracycl

Details Method for the production of 9-amino-6-demethyl-6-deoxytetracycl Method for the production of 9-amino-6-demethyl-6-deoxytetracycl

1992-08-13

1993-09-28

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Tetracyclo naphthacene configured ring system having at...

C07C23566

Patent

active

052487970

ABSTRACT:
The invention relates to a novel method for producing [4S-(4alpha, 12aalpha)]-9-amino-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3, 10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide, hereinafter called 9-amino-6-demethyl-6-deoxytetracycline, which compound is a valuable intermediate for synthesis of tetracyclines.

REFERENCES:
patent: Re26253 (1967-08-01), Petisi
patent: Re26271 (1967-09-01), Boothe
patent: 3043875 (1962-07-01), Beereboom
patent: 3226436 (1965-12-01), Petisi
patent: 3338963 (1967-08-01), Petisi et al.
Boothe et al, J. Amer. Chem. Soc., vol. 82, pp. 1253-1254 (1960).
Spencer et al, J. Med. Chem., vol. 6, pp. 405-407 (1963).

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