Method for the production of 6-hydroxynicotinic acid

Details Method for the production of 6-hydroxynicotinic acid Method for the production of 6-hydroxynicotinic acid

1987-03-24

1988-04-19

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435117, 435122, 435131, 435189, 435190, C12P 1710

Patent

active

047389249

ABSTRACT:
Process for the production of 6-hydroxynicotinic acid by biotechnological methods. Nicotinic acid is enzymatically hydroxylated in the presence of equivalent quantities of magnesium or barium ions with the help of nicotinic acid-hydroxylating microorganisms. The resultant magnesium or barium salt of the 6-hydroxynicotinic acid is separated from the reaction mixture. Then the 6-hydroxynicotinic acid is freed from the separated salts. Examples of the microorganism are the species Pseudomonas, Bacillus or Achromobacter, for example, Achromobacter xylosoxydans. Preferably the enzymatic hydroxylation is carried out at 20.degree. to 40.degree. C. and a pH of 5.5 to 9.0 under aerobic conditions.

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Hunt et al.--Biochem. Journal, vol. 69, pp. 170-173 (1958).
Hirschberg et al., Journal of Bacteriology, vol. 108, No. 2, pp. 751-756.

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