Method for the production of (-)-4-difluoromethyl-ornithine

Details Method for the production of (-)-4-difluoromethyl-ornithine Method for the production of (-)-4-difluoromethyl-ornithine

1991-06-27

1993-06-08

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435106, 435115, 435195, 435114, C12P 1300, C12P 1308, C12P 1310, C12N 914

Patent

active

052178862

ABSTRACT:
The present invention is directed to a process for producing (-) 2-substituted-ornithines comprising contacting a 2-substituted-piperidone with L-.alpha.-E-aminocaprolactam-hydrolas in the presence of a divalent cation.

REFERENCES:
T. Fukumura, Plant & Cell Physiol vol. 18, pp. 1173-1176, (1977).
K. Plhackova et al., Folia Microbiol 27, pp. 382-389 (1982).
T. Fukumura et al., FEBS Letters vol. 89, pp. 298-300 (1978).

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