Method for the production of 1-amino-3-phenyluracil derivatives

Details Method for the production of 1-amino-3-phenyluracil derivatives Method for the production of 1-amino-3-phenyluracil derivatives

2006-04-25

2006-04-25

Rao, Deepak (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S309000, C544S310000, C544S312000, C544S313000

Reexamination Certificate

active

07034156

ABSTRACT:
The present invention relates to a novel process for preparing known 1-amino-3-phenyluracil derivatives, to novel 1-amino-6-hydroxy-3-phenyldihydro-2,4(1H,3H)pyrimidinedione derivatives of the formula (II)in whichR1is hydrogen, cyano, nitro or halogen,R2is cyano, nitro, halogen or optionally substituted alkyl or alkoxy,R3is hydrogen, hydroxyl, mercapto, amino, hydroxyamino, hydrazino, halogen, or one of the radicals —R6, -Q-R6, —NH—R6, —NH—O—R6, —NH—SO2—R6, —N(SO2—R6)2, —CQ1-R6, —CQ1-Q2-R6, —CQ1-NH—R6, -Q2-CQ1-R6, —NH—CQ1-R6, —N(SO2—R6)(CQ1-R6), -Q2-CQ1-Q2-R6, —NH—CQ1-Q2-R6or -Q2-CQ1-NH—R6,whereQ is O, S, SO or SO2,Q1and Q2are each independently oxygen or sulphur andR6is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl,R4is hydrogen, halogen or optionally substituted alkyl, andR5is fluorine- and/or chlorine-substituted alkyl,as intermediates for the 1-amino-3-phenyluracil derivatives, and to a process for preparing the intermediates.

REFERENCES:
patent: WO 98/27068 (1998-06-01), None

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