Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1999-05-14
2001-09-18
Jones, Dameron L. (Department: 1619)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
Reexamination Certificate
active
06290975
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the use of an agent which maintains or improves the permeability barrier of the gum in the manufacture of an oral composition for the treatment or prevention of gum disease.
2. The Related Art
Efficient dental hygiene is a primary requirement in maintaining good oral health. Poor oral health manifests itself in many forms, for example tooth decay, gum disease, mouth ulcers etc.
In addition, stained teeth and diseased gums are a cosmetically undesirable consequence of poor oral hygiene.
Improved oral hygiene is, therefore, a much sought goal and there is much prior art relating to various methods which may be employed in achieving this consumer positive. For example, antimicrobial agents such as chlorhexidine and Triclosan (2′, 4,4′-trichloro, 2-hydroxy-diphenyl ether) have been used in dentifrice compositions and are employed to reduce bacterial build up and, therefore, plaque production on the teeth. Reducing the formation of plaque helps reduce the staining of teeth and also helps prevent gum disease.
Despite these prior proposals, there is still a need for an effective method for improving oral care.
We have now surprisingly found, that providing a protective barrier over the gum is capable of providing an improved benefit in oral hygiene.
It is thought that by improving the permeability barrier of the gum that the cosmetic disadvantages of gum disease can be prevented.
SUMMARY AND DETAILED DESCRIPTION OF THE INVENTION
Accordingly the invention concerns the use of an agent which maintains or improves the permeability barrier of the gum in the manufacture of an oral composition for the treatment or prevention of gum disease.
Preferably, the agent is capable of reducing the permeability coefficient of the gum by at least 20%, more preferably at least 30% and especially by at least 40% with respect to the coefficient effected by phosphate buffered saline (PBS).
More preferably the agent is a fat or an oil, most preferably an oil and especially an oil selected from the group consisting of silicone oil, vegetable oil, animal oil and mineral oil.
An alternative agent according to the invention is a synthetic ester such as isopropyl myristate.
Where the agent is a fat it is preferable that it is a fat, e.g. a triglyceride, with a melting point of below 50° C.
By oral composition is meant any composition applied to the oral cavity, e.g. toothpaste, mouthwash, gel, cream, powder, lozenge, mousse, etc. It may also be a composition formulated in a multi-compartment type dispenser. Typically, the agent will comprise almost entirely of the agent; preferably from 0.01 to 30%, more preferably from 0.1 to 20% and especially from 0.1 to 10% by weight of the oral position according to the invention.
The present invention will be further illustrated by way of example.
EXAMPLE
Sample
1
PBS (1)
2
Akogel (2)
3
Sunflower oil (3)
4
Borage oil (4)
5
Petroleum jelly (5)
6
silicane oil (6)
7
silicane oil (7)
(1) Phosphate buffered saline
(2) Vegetable fat ex Karlshamns (Lot 4594 1996-02-22)
(3) ex Anglia oils (753-97 RBWD)
(4) ex Anglia oils
(5) White soft paraffin jelly ex Hansen & Rosenthal Pioneer (6954)
(6) Heavy silicane ex Dow Corning (DC200/5000 cps)
(7) Light silicane ex Dow Corning (DC200/350 cps)
Specimens of gingiva were obtained from animals used for surgical research. The gingiva was taken from the region between the incisor and premolar teeth in the maxilla. The specimens were taken within 2 hours of death, excess muscle and fat removed and the tissue was snap frozen in liquid nitrogen and stored at −70° C. until use.
The specimen was thawed completely before use in the permeability experiment. In order to prevent cracking during thawing, the specimen was placed in a plastic petri-dish at room temperature for 5-10 min. The specimen was then removed from PBS and the epithelium was damped dry. Pieces of tissue, about 6 mm in diameter, were cut from the specimen using a blade, excess muscle was removed. Lipids were extracted from excised gum tissue using chloroform:methanol (2:1 v/v) containing 1% hydrochloric acid and 4% water. The tissue was immersed for 60 min in this mixture and then washed with PBS prior to treatment with the agent. The agent had been applied to each piece, which was clamped between the two parts of the chamber described below.
Application of agents
The following protocol was used to deliver the agent:
The tissue was rinsed in PBS and blotted dry. The agent was applied by brushing gently and evenly over the epithelial surface of the tissue using an interspace toothbrush. The treated tissue was left for 1 min and then rinsed in PBS by dipping 5 times in 5 s.
The treated tissue was then loaded into flow through chambers for the permeability experiment.
REFERENCES:
patent: 4409202 (1983-10-01), Witzel et al.
patent: 4971788 (1990-11-01), Tabibi et al.
patent: 5100919 (1992-03-01), Ulrich et al.
patent: 5344641 (1994-09-01), Gaffar et al.
patent: 5637290 (1997-06-01), Sodis et al.
patent: 5833955 (1998-11-01), Kleinberg et al.
patent: 34 07 860 (1984-03-01), None
patent: 0 450 598 (1991-03-01), None
patent: 0 470 019 (1992-05-01), None
patent: 709132 (1954-05-01), None
patent: 796498 (1958-06-01), None
patent: 2 219 937 (1989-12-01), None
patent: 58128313 (1983-07-01), None
patent: 2078576 (1997-05-01), None
patent: 92/02216 (1992-02-01), None
patent: 93/01723 (1993-02-01), None
patent: 95/35351 (1995-12-01), None
patent: 96/26707 (1996-09-01), None
patent: 97/15277 (1997-05-01), None
Creeth Jonathan Edward
Stead William John
Williams David Michael
Honig Milton L.
Jones Dameron L.
Unilever Home & Personal Care USA , division of Conopco, Inc.
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