Method for the prevention of gastro-intestinal ulcer caused by a

Details Method for the prevention of gastro-intestinal ulcer caused by a Method for the prevention of gastro-intestinal ulcer caused by a

1977-05-11

1981-01-27

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

A61K 31505

Patent

active

042475546

ABSTRACT:
A method for preventing gastro-intestinal ulcer caused by a non-steroidal anti-inflammatory agent, which comprises administering an effective amount of a quinazolinone of the formula, ##STR1## wherein R.sub.1 is C.sub.1-3 alkyl, cyclopropylmethyl or 2,2,2-trifluoroethyl, R.sub.2 is halogen, C.sub.1-3 alkyl or C.sub.1-3 alkoxy, and R.sub.3 is phenyl or thienyl, or a non-toxic pharmaceutically acceptable salt thereof in combination with a pharmaceutically effective amount of the non-steroidal anti-inflammatory agent.

REFERENCES:
patent: 3712892 (1973-01-01), Inaba et al.
patent: 3812118 (1974-05-01), Yamamoto et al.
patent: 3859237 (1975-01-01), Inaba et al.
patent: 3937801 (1976-02-01), Lippmann
Cutting-Handbook of Pharmacology, 4th Ed., pp. 618-625, (1969).

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