Method for the prevention and treatment of scars with enzymes

Details Method for the prevention and treatment of scars with enzymes Method for the prevention and treatment of scars with enzymes

1983-08-04

1985-06-18

Rosen, Sam

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 3748

Patent

active

045240655

ABSTRACT:
A method for the prevention of and for the dissolution of mammalian cicatrices such as acne scars, keloids and other hypertrophic scars comprising intralesional injection of effective amounts of a pharmacologically suitable solution of the enzyme collagenase, by itself, and collagenase in combination with the enzyme hyaluronidase.

REFERENCES:
patent: 3678158 (1972-07-01), Sussman
patent: 3705083 (1972-12-01), Chiulli et al.
patent: 4174389 (1979-11-01), Cope
patent: 4338300 (1982-07-01), Gelbard
Seifter, S., et al., In Enzymes, 3rd ed., pp. 649-697, 1971.
Lee, K. K., et al., Collagenase Therapy for Decubitus Ulcers, Genetics 30: 91, 1975.
Mazurek, T., In Collagenase, ed. Mandl, I., 1st ed., Gordon and Breach, Science Publishers, p. 171, 1970.
Zimmerman, W. E., In Collagenase, ed. Mandl, I., 1st ed., Gordon and Breach, Science Publishers, p. 131, 1970.
Sussman, B. M., et al., Injection of Collagenase in the Treatment of Herniated Lumbar Disk, JAMA 245: 730-732, 1981.
King, G. D., et al., Keloid Scars, Surg. Clin. N. Amer. 50: 595, 1970.
Lwebaga-Mukasa, P. Collagenase Enzymes from Clostridium: Characterization of Individual Enzymes, Biochemistry, 15: 4736, 1976.
Prugnaud et al.--Chem. Abst. vol. 78, (1973), p. 88621x.
Lee et al.-Geriatrics vol. 30, No. 91, (1975), pp. 91-93, 97 and 98.
Horton et al.-Plastic & Reconstructive Surgery, vol. 52, No. 503, (1973), pp. 503-510.

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