Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1985-03-27
1987-02-24
Rosen, Sam
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
A61K 3748
Patent
active
046456686
ABSTRACT:
The method for preventing and for treating mammalian cicatrices such as keloids, acne scars, hypertrophic scars, wrinkles, cellulite and neoplastic fibrosis which comprises intra-dermal injection of effective amounts of a pharmacologically suitable solution of the enzymes collagenase, elastase, papain, plasminogen activator, plasmin, mast cell protease or lysosomal hydrolase, individually, and one or more of such enzymes in combination with the enzyme hyaluronidase.
REFERENCES:
patent: 3003917 (1961-10-01), Beiler et al.
patent: 3019167 (1962-01-01), Innerfield
patent: 3019171 (1962-01-01), Bloch et al.
patent: 4197291 (1980-04-01), Klein et al.
patent: 4276281 (1981-06-01), Crikelair
patent: 4524065 (1985-06-01), Pinnell
Kuhn III, C. et al., The Induction of Emphysema with Elastase, II. Changes in Connective Tissue, Lab. Invest. 34: 372-380, 1976.
Janoff, A. et al., Experimental Emphysema Induced with Purified Human Neutrophil Elastase: Tissue Localization of the Instilled Protease, Am. Review of Respiratory Disease 115: 461-478, 1977.
Senior, R. M. et al., The Induction of Pulmonary Emphysema with Human Leukocyte Elastase, American Review of Respiratory Disease, 116: 469-475, 1977.
Gross, P. et al., Experimental Emphysema: Its Production with Papain in Normal and Silicotic Rats, Arch. Environ. Health, 11: 50-58, 1965.
Hayes, J. A. et al., The Pathology of Elastase-Induced Panacinar Emphysema in Hamsters, The Journal of Pathology, 117 No. 1: 1-14, 1975.
Goldring, I. P. et al., On the Production of Emphysema in Syrian Hamsters by Aerosol Inhalation of Papain, Arch. Environ. Health, 16: 59-60, 1968.
Liotta, L. A. et al., Identification of a Type V Collagenolytic Enzyme, Biochemical and Biophysical Research Communications, 98: 184-190, 1981.
Liotta, L. A. et al., Partial Purification and Characterization of a Neutral Protease Which Cleaves Type IV Collagen, Biochemistry, 20: 100-104, 1981.
Werb, Z. et al., Degradation of Connective Tissue Matrices by Macrophages. I. Proteolysis of Elastin, Glycoproteins, and Collagen by Proteinases Isolated from Macrophages, Journal of Experimental Medicine, 152: 1340-1357, 1980.
Moscatelli, D. et al., in Proteinases and Tumor Invasion, Raven Press, pp. 143-152, 1980.
Biospecifics, NV
Plottel Roland
Rosen Sam
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