Method for the preservation of biologically-active material

Details Method for the preservation of biologically-active material Method for the preservation of biologically-active material

2005-01-11

2005-01-11

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S488000, C424S184100, C514S001000, C514S002600, C514S04400A, C514S055000, C435S260000

Reexamination Certificate

active

06841168

ABSTRACT:
Biologically-active material can be preserved by a method of desiccation, without lyophilisation, in a matrix of glassy trehalose. The method involves forming a coacervate of the biologically-active material and chitosan and then dehydrating mixture of coacervate and trehalose solution. In a cycle time much shorter than a typical freeze drying process biologically-active material, such as viruses, proteins and nucleic acids, can be preserved to provide a material that can be rehydrated. The invention is especially useful for the production of vaccines from preserved material.

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