Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2005-08-30
2005-08-30
Jones, Dameron L. (Department: 1616)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001110, C424S009100, C534S014000
Reexamination Certificate
active
06936240
ABSTRACT:
The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER). The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2˜14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.
REFERENCES:
patent: 6344178 (2002-02-01), Alberto et al.
Neutral and Stereospecific Tc-99m Complexes by Zhi-Ping Zhuang et al., Nuclear Medicine & Biology, vol. 26, pp. 217-224, 1999.
Preparation of99mTc-N2S2conjugates of chrysamine G. by Nancy A. Dezutter et al., Journal of Labelled Compounds and Radiopharm., 42, pp. 309-324 (1999).
Small and Neutral TcvO BAT, Bisaminoethanethiol (N2S2) Complexes, by Shunichi Oya et al., Nuclear Medicine & Biology, vol. 25, pp. 135-140, 1998.
Choi Sang Mu
Choi Sun Ju
Gwon Hui Jeong
Han Kwang Hee
Hong Young Don
Bachman & LaPointe P.C.
Jones Dameron L.
Korea Atomic Energy Research Institute
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