Method for the preparation of sevoflurane

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Reexamination Certificate

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C568S683000

Reexamination Certificate

active

08058482

ABSTRACT:
A method for the preparation of (CF3)2CHOCH2F (Sevoflurane) is presented, which comprises providing a mixture of (CF3)2CHOCH2Cl, potassium fluoride, water, and a phase transfer catalyst and reacting the mixture to form (CF3)2CHOCH2F.

REFERENCES:
patent: 4874901 (1989-10-01), Halpern et al.
patent: 6100434 (2000-08-01), Bieniarz et al.
patent: 6362273 (2002-03-01), Martin et al.
patent: 2003/0158435 (2003-08-01), Joyce et al.
patent: 0 129863 (1985-02-01), None
patent: 2219292 (1989-12-01), None
patent: WO 9821219 (1998-05-01), None
Bieniarz et al., An efficient and environmentally friendly synthesis of the inhalation anesthetic sevoflurane, Journal of Fluorine Chemistry, vol. 106, Jun. 2000, pp. 99-102.
Halpern et al., Top 10 Opportunities to Improve Process Performance and Profit Using Phase Transfer Catalysis, Industrial Phase Transfer Catalysis, Issue 16, 2002, pp. 1-16.
Ramakrishna et al., “A Safe and Efficient Process for the Synthesis of the Inhalation Anesthetic Sevoflurane” Organic Process Research & Development, 2000, 4, 581-584.
Halpern, et al., “Replacement of Halogens by Fluorine” Chemistry of Organic Fluorine Compounds II, In: Hudlicky and Pavlath, Chemistry of Organic Fluorine Compounds II a Critical Review, ACS Monograph 187, American Chemical Society, Washington, DC, 1995, 172-198.

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